• Whereas Sororin is dispensable in the absence of Wapl

  2022-02-15

  

  Whereas Sororin is dispensable in the absence of Wapl [14], overexpressed Haspin only partly supports cohesion in Sororin-depleted cells. Thus, although Haspin and Sororin have functional similarities, they are not fully redundant at the centromere. Haspin may have a mitosis-specific role in maintai

• Ras small GTPases are critical molecular

  2022-02-15

  

  Ras small GTPases are critical molecular switches that connect extracellular signals to intracellular signaling pathways initiated by membrane receptors, such as growth factor receptors and G protein-coupled receptors (Simanshu et al., 2017). When shifting between active GTP-bound and inactive GDP-b

• After establishing improved GSNOR potency some

  2022-02-15

  

  After establishing improved GSNOR potency, some of the potent inhibitors were further evaluated for microsomal stability and CYP inhibition studies (). Majority of the tested analogs revealed high metabolic stability in human and rat liver microsomes, and moderate to low stability in mouse liver mic

• br Materials and methods br Results br Discussion To underst

  2022-02-14

  

  Materials and methods Results Discussion To understand the molecular basis for how ghrelin secretion is regulated at the cellular level, we identified the full repertoire of 7TM receptors and G proteins in gastric ghrelin 5-Hydroxy-CTP synthesis and functionally characterized the majority o

• br Myelin and metabolism In addition

  2022-02-14

  

  Myelin and metabolism In addition to promoting efficient Naloxone propagation, myelin is also critical for trophic and metabolic support of axons [56]. To provide metabolites to axons accurately, glia must ‘know’ the metabolic requirements of axons. Could electrical activity by axons function as

• In addition to the role of TGR the FXR FGF

  2022-02-14

  

  In addition to the role of TGR5, the FXR-FGF15/19 axis has been implicated in other aspects of glucose metabolism and metabolic disorders. In humans, both obesity and type 2 diabetes mellitus (T2DM) are associated with lower plasma FGF19 levels [67,68]. A derivative of the naturally occurring FXR ag

• To further investigate its role in

  2022-02-14

  

  To further investigate its role in stresses tolerance, OsGly I was overexpressed in transgenic rice. qRT-PCR and zymologic determination showed that TG003 level of OsGly I and the glyoxalase I activity were significantly increased to different extent in the transgenic overexpression lines (Fig. 1,

• br Voltage dependent anion channel VDAC is

  2022-02-14

  

  Voltage-dependent anion channel VDAC is a ubiquitous protein showing well conserved structural and functional properties in spite of major variations in its sequence (for review see [50]). Most of what we know about VDAC electrophysiological properties (for reviews, see [51], [52]) was initially

• br Funding Our work in

  2022-02-14

  

  Funding Our work in this field was supported by CNRSLIA528, Agence Nationale de la Recherche 06-Neuro, Agence Nationale de la Recherche MNMP 2009. Introduction GABA and the GI motility The role of GABA in the modulation of GI motility is quite complex and not fully understood, since GABA-i

• br Role of FPRs in regulating the inflammatory response Anne

  2022-02-14

  

  Role of FPRs in regulating the inflammatory response Annexin I is a glucocorticoid-regulated protein possessing both pro- and anti-inflammatory activity that might be mediated, in part, by FPR activation [35]. Expressed in a variety of cell types, annexin I is particularly abundant in neutrophils

• Apicidin Receptor activator of NF B ligand RANKL and macroph

  2022-02-14

  

  Receptor activator of NF-κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) stimulate the generation of osteoclast Apicidin [10], [11], [12], [13]. In response to sphingosine 1-phosphate (S1P) signaling, osteoclasts then attach to regions of bone undergoing resorption [14]. In RA wh

• This study appears to provide

  2022-02-12

  

  This study appears to provide an additional example, albeit an unanticipated one, of the importance of renal ETB receptor function in the normal control of blood pressure and salt and water homeostasis. ETB receptor-deficient rats, collecting duct-specific ETB receptor knockout mice, and rats chroni

• br Funding The research for this

  2022-02-12

  

  Funding The research for this paper is conducted as part of a PhD thesis at Pasteur Institute of Iran and it was financially supported by Pasteur Institute of Iran and the Iranian Centre for Communicable Diseases. Conflict of interest Acknowledgments Introduction The viral enzyme integr

• br Conclusion The following is

  2022-02-12

  

  Conclusion The following is the supplementary data related to this article. Conflict of interest Author contributions Heart transplantation is the most important treatment for end-stage heart failure. Ischemia/reperfusion injury is a common condition during transplantation surgery and is

• N1-Methylpseudouridine We started our investigation by evalu

  2022-02-12

  

  We started our investigation by evaluating the impact of changes to the piperidine moiety of (). As demonstrated with morpholine and piperazine , attenuation of nitrogen basicity resulted in complete loss of activity, suggesting that a basic heterocyclic nitrogen is important for potent inhibition

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